
姓名:黄嘉良
职称:特聘教授
电子邮箱:klwonggary@gmail.com
个人简介:
黄嘉良,男,1979年11月生,中国香港人,汉族,博士,内蒙古自治区政协委员,国家教育部长江学者,bevitor伟德官网网址科炬特聘教授。主要从事图像引导癌症治疗、镧系元素化学、发光材料和光谱学、稀土绿色提取和应用等研究。发表学术论文200余篇,索引10000余次,H因子63,多项国际发明专利。目前担任《Journal of Luminescence》编辑、ChemPlusChem国际顾问委员会成员。
研究方向:
化学生物学(EBAN1、Plk1、Cyclin(s)等一系列过表达肿瘤蛋白的成像、抑制和机理研究,及其光激活疗法),镧系元素化学和光谱学,稀土绿色提取和应用。
教育背景:
1999-2002年,香港城市大学应用化学理学,学士;
2002-2006年,香港大学化学,博士;
2008-2009年,英国杜伦大学,英国皇家学会化学系博士后研究员。
工作简历:
2009-2010年,香港浸会大学化学系替代助理教授;
2011-2017年,香港浸会大学化学系研究助理教授、助理教授、副教授;
2017-2021年,香港浸会大学化学系教授;
2017-2022,香港浸会大学化学系,系主任
2021-2023年,香港浸会大学化学系讲座教授;
2023年至今,香港理工大学应用生物及化学科技学系讲座教授
2025年至今,bevitor伟德官网网址特聘教授
个人荣誉:
1. 英国皇家学会奖学金,2008-2009
2. 欧洲稀土金属和锕元素协会,2015年青年科学家奖
3. 香港浸会大学,2019年杰出学术研究表现奖
4. 香港浸会大学,2017年杰出青年研究学者奖
5. Journal of Materials Chemistry C 2016年杰出审稿人
6. 英国华威大学IAS国际访问奖学金,2020
7. 高等学校科学研究优秀成果奖(科学技术)-自然科学奖二等奖,2020
主要业绩:
代表性学术论文
1. Yue Wu, Yuen-Ting Wong, Yik-Hoi Yeung, Pak-Lun Lam, Ho-Fai Chau, Wing-Sze Tam, Qian Zhang, William C. S. Tai* and Ka-Leung Wong*, ‘Peptide Multifunctionalization via Modular Construction of trans-AB2C Porphyrin on Resin’, Advanced Science, (2025) 12, 2409771.
2. W. Thor, H.-Y. Kai, Y.-H. Yeung, Y. Wu, Y. Zhang, L. J. Charbonnière*, P. A. Tanner* and K.-L. Wong*, ‘Unearthing the Real-Time Excited State Dynamics from Antenna to Rare Earth Ions Using Ultrafast Transient Absorption’, Journal of the American Chemical Society Au, (2024) 4, 3813-3822.
3. Y. Wu, H.-F. Chau, Y.-H. Yeung, W. Thor, H.-Y. Kai, W.-L. Chan* and K.-L. Wong*,’Versatile synthesis of multivalent porphyrin–peptide conjugates by direct porphyrin construction on resin’, Angewandte Chemie International Edition, (2022) e202207532.
4. S. Zha, H.-F. Chau, W. Y. Chau, L. S. Chan, J. L., K. W. Lo, W. C.-S. Cho, Y. L. Yip, S. W. Tsao, P. J. Farrell, J. M. Di*, G.-L. Law*, H. L. Lung* and K-L Wong*, ‘Dual-targeting peptide-guided approach for precision delivery and cancer monitoring by using a safe upconversion nanoplatform’, Advanced Science, (2021) 2002919.
5. Y. Wu, H.-F. Chau, W. Thor, K. H. Y. Chan, X. Ma, W.-L. Chan*, N. J. Long* and K.-L. Wong*, ‘Solid-phase peptide macrocyclization and multifunctionalization via dipyrrin construction’, Angewandte Chemie International Edition, (2021) 60(37), 20301-20307.
6. W. Thor, Y. Wu, L. Wang, Y. Zhang, P. A. Tanner* and K.-L. Wong*, ‘First reported charging and ultralong phosphorescence of lanthanide facilitated organic complex’, Nature Communications, (2021) 12, 1-9.
7. L. Jiang, H. L. Lung, T. Huang, R. Lan, S. Zha, L. S. Chan, W. Thor, T.-H. Tsoi, H.-F. Chau, C. Boreström, S. Cobb, S. W. Tsao, Z.-X. Bian, G.-L. Law, W.-T. Wong, W. C.-S. Tai, W. Y. Chau, Y. Du, L. H. X. Tang, A. K. S. Chiang, J. M. Middeldorp, K.-W. Lo, N.-K. Mak*, N. J. Long*, and K.-L. Wong*, ‘Reactivation of Epstein Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function’, Proceedings of National Academy of Science USA, (2019) 26614-26624.
8. J. Zhang, W.-L. Chan, C. Xie, Y. Zhou, P. Maity, G. T. Harrison, A. Amassian, O. Mohammed, P. A. Tanner*, W.-K. Wong*, and K.-L. Wong*, ‘Impressive near-infrared brightness and singlet oxygen generation from strategic lanthanide–porphyrin double–decker complexes in aqueous solution’, Light: Science & Applications, (2019) 8, 46.
9. L. Jiang, R. Lan, T. Huang, C.-F. Chan, H. Li, S. Lear, J. Zong, W.-Y. Wong, M. M.-Lan Lee, B. D. Chan, W.-L. Chan, W.-S. Lo, N.-K. Mak,* M. L. Lung, G. S. Taylor, Z.-X. Bian, W. C. S. Tai, G.-L. Law,* W.-T. Wong,* S. L. Cobb* and K.-L. Wong*, ‘EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein–Barr virus’, Nature Biomedical Engineering, (2017) 0042. (Highlighted in Nature Biomedical Engineering, 2017, 0059 and Cell Chemical Biology, 2017, 647-648)
10. Tao Zhang, Rongfeng Lan, Chi-Fai Chan, Ga-Lai Law, Wai-Kwok Wong and Ka-Leung Wong,* ‘In vivo selective cancer tracking gadolinium eradicator as new generation photodynamic therapy agent’, Proceedings of National Academy of Science USA, 111 (2014) E5492-E5497.
部分授权专利
(1) Zinc-binder based EBNA1-specific compounds, US11046731B2
(2) Lanthanide toolbox for organelle specific molecular imaging with multi-color, US10787465B2
(3) Therapeutic inhibitor for EBV-associated tumor with tailor responsive optical imaging, US10842846B2
(4) Urinary polyamines as prostate cancer detection biomarkers, US10527627B2
(5) Lanthanide toolbox for multi-modal, non-invasive tumor specific theranostic prodrugs, US10183027B2